Steam version of Penumbra - Black Plague : Crash at first level.

[Mudbill]

That's an OpenGL error, which either indicates invalid code in Penumbra or (more likely) a difference in your video driver's OpenGL implementation. Though considering how many have this issue, I'm reluctant at saying just that. Perhaps it has to do with how old Penumbra is, and newer drivers have maybe changed some things that they used? I believe it uses deprecated OpenGL functions by today's standards. Perhaps an old driver makes a difference?