ESC issue

[Your Computer]

The Esc keyboard shortcut is normally within the application scope, and so applications can do what they wish with it, even having it do nothing when triggered. In order for keyboard shortcuts that are within the scope of the application to work, the application must have keyboard focus. Note, just because the window is in fullscreen mode, that doesn't mean it has keyboard focus, let alone complete control of the Esc key. Ctrl + Esc shortcut is a Windows reserved shortcut within the global scope and so should work every time (except perhaps when Windows has "locked up").