Worst/ weirdest/ funniest pop culture reference (or easter egg) in a game?

[Razalhague]

The strangest I've personally encountered is this dialogue from the first Fallout:
Me: "C D E D B D Ducks!"
NPC: "M R Not Ducks!"
Me: "O S M A! C D E D B D Wings?"
NPC: "Y I B M R Ducks"

Apparently it's a reference to an even older game called Wasteland. Bonus points if you can figure out what it means without googling.