Would it be possible?

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Well on the plus side, it would give the CS a relatively small, clearly defined but still logical environment which I think could make for a short, but very rich experience. Tight restrictions like that can really help in focussing ones creativity which often makes for a more interesting and better thought-out result.

On the downside, you'd need a ton of custom assets. I think there's barely anything from Amnesia you can reuse without it looking really weird, at least when it comes to the outside areas of the ship. And modeling THIS would be quite a challenge...