Yes, it is possible.
Create a script area and call it WhateverYouLike.
AddEntityCollideCallback("Player", "WhateverYouLike", "KillThePlayer", false, 1);
void KillThePlayer(string &in asParent, string &in asChild, int alState)
* Type can be: BloodSplat, Claws or Slash.
* void GivePlayerDamage(float afAmount, string& asType, bool abSpinHead, bool abLethal);
GivePlayerDamage(1000, "BloodSplat", true, true);
//player dies, number has to be 100+ to kill the player when he wasn't damaged yet
//1000 = Amount of Damage, "BloodSplat" = Animation played on the screen when getting damage
//first true = make the player spin when he gets damaged
//second true = makes it lethal damage so you actually die from it
The developers actually used
Up to you how you want to do it.